Nigel John Burroughs

CelFDrive automates high-resolution 3D imaging of cells using deep learning for efficient detection of rare events in large populations.

The paper maps the ordered molecular events of SAC silencing at single kinetochores using MAD2 levels, revealing sequential unbinding, structural reorganization, and stabilization processes.

The paper uses Bayesian inference to analyze kinetochore dynamics in human cells, identifying spatial and temporal organization patterns during mitosis.

This study shows that activating KIF2C reduces chromosome segregation errors and aneuploidy in early human embryos, improving IVF outcomes.

The paper introduces a Bayesian method to infer multi-point macromolecular architecture at nanometre resolution, showing heterogeneity in metaphase kinetochore conformation.