Andrew D. McAinsh

CelFDrive automates high-resolution 3D imaging of cells using deep learning for efficient detection of rare events in large populations.

The paper maps the ordered molecular events of SAC silencing at single kinetochores using MAD2 levels, revealing sequential unbinding, structural reorganization, and stabilization processes.

The paper uses Bayesian inference to analyze kinetochore dynamics in human cells, identifying spatial and temporal organization patterns during mitosis.

The paper investigates the causes of multi-nucleation in two-cell human embryos and finds that spindle and metaphase plate incoherence during the first mitosis leads to this phenomenon.

This study shows that activating KIF2C reduces chromosome segregation errors and aneuploidy in early human embryos, improving IVF outcomes.

This study investigates the role of the chromosome periphery in oocyte meiosis, showing its impact on chromosome structure and meiotic progression in human and mouse oocytes.

The paper introduces a Bayesian method to infer multi-point macromolecular architecture at nanometre resolution, showing heterogeneity in metaphase kinetochore conformation.

This study shows Bub1 is not essential for SAC response to unattached kinetochores in human cells, supporting the dual pathway model.

This study shows that epithelial-to-mesenchymal transition increases chromosome mis-segregation through microtubule detyrosination, which can be reversed by parthenolide.