Spatial Conformation of Pancreatic Cancer Is Associated with Disease Recurrence after Curative-Intent Total Neoadjuvant Therapy
Luis Humberto Cisneros, Merih Deniz Toruner, Zafar Siddiqui, Andrea V. Maraone Garzaro, Miranda Lin, Alex Xiao, Cornelius A. Thiels, Mark Joseph Truty, Ben George, Khalid Jazieh, Rob McWilliams, Carlo C. Maley, Christopher Hartley, Rofyda Essam Elhalaby, Paul J. Dizona, , Ryan Michael Carr
This paper quantifies spatial cancer-stroma topology in post-TNT PDAC and shows it independently predicts disease-free survival better than traditional response assessments.
bioRxiv · Nov 3, 2025 · PreprintCancer Biology