Zhenyong Wu

This paper introduces a DNA framework vesicle nanoreactor that enables programmable and quantifiable membrane fusion by controlling geometry and kinetics.

This study identifies Doc2 as the major Ca2+ sensor for asynchronous release and shows that syt7 supports vesicle docking, with combined effects on synaptic function.

This study shows that SYT9 regulates spontaneous neurotransmitter release in striatal neurons by controlling substance P secretion, without triggering rapid synaptic vesicle exocytosis.

This study shows that synaptotagmin-1 multimerization via the juxtamembrane linker is essential for both spontaneous and evoked neurotransmitter release.

This study shows that polybasic patches in both C2A and C2B domains of Synaptotagmin-1 are required for evoked neurotransmitter release, but not for spontaneous release or the readily releasable vesicle pool.