Author

Yuanfang Chen

National Center for Nanoscience and TechnologyORCID 0000-0002-4404-5302Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Yuhe Renee YangiD· 3 shared Chunying CheniD· 2 shared Dongsheng LiuiD· 2 shared Jiayi LiiD· 2 shared Jinqian LiiD· 2 shared Li‐Tang YaniD· 2 shared Linqi ZhangiD· 2 shared Niannian LviD· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Yuhe Renee YangORCID

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3 papers

Recent·Most cited

IgG-Bridging-Seeded Synergistic Aggregation of SARS-CoV-2 Spikes Underlies Potent Neutralization by A Low-Affinity Antibody

Niannian Lv, Peng Chen, Xiaobin Dai, Hu Xu, Ziheng Li, Zelin Shan, Jinqian Li, Fenglin Guo, Yuanfang Chen, Jiayi Li, Yiqian Huang, Guizhi Dong, Yifan Jiang, Liang Chen, Xuanyu Nan, , Yuhe Renee Yang

This paper identifies a low-affinity SARS-CoV-2 antibody, P5-1C8, that neutralizes Omicron JN.1 through IgG-mediated spike aggregation rather than direct binding.

Advanced Science · Dec 7, 2025Peer-reviewedCell Biology

DNA Framework Nanoreactor for Programmable Membrane Fusion

Qian Shi, Qiulan Yang, Fan Li, Min Bao, Shengwen Wang, Kui Huang, Jiayi Liu, Yunyun Wang, Yuanfang Chen, Yuhe Renee Yang, Xin Bian, Zhenyong Wu, Yang Yang

This paper introduces a DNA framework vesicle nanoreactor that enables programmable and quantifiable membrane fusion by controlling geometry and kinetics.

bioRxiv · Oct 28, 2025 · PreprintBioengineering

Distinct Binding Modes of Inter-Spike Cross-Linking Suggest a Supplementary Mechanism for SARS-CoV-2 Antibody Neutralization

Xuanyu Nan, Yujie Li, Rui Zhang, Ruoke Wang, Niannian Lv, Jiayi Li, Yuanfang Chen, Bini Zhou, Yangjunqi Wang, Ziyi Wang, Jiayi Zhu, Jing Chen, Jinqian Li, Wenlong Chen, Qi Zhang, , Yuhe Renee Yang

This study uses cryo-EM to show that the W328-6H2 antibody forms different structures with SARS and Omicron BA.1 spike proteins, revealing a supplementary neutralization mechanism beyond RBD-Fab binding.

Nature Communications · Dec 4, 2024Peer-reviewedImmunology