Q1020R in the spike proteins of MERS-CoV from Arabian camels and recent human cases confers resistance against soluble human DPP4
Nianzhen Chen, Hannah Kleine‐Weber, Khaled Riyad Alkharsah, Michael Winkler, Asisa Volz, Marcel A. Müller, Victor M. Corman, Christian Drosten, Markus Hoffmann, Stefan Pöhlmann
The paper compares MERS-CoV variants from Arabian and African camels, showing Arabian viruses are more resistant to inhibition by human soluble DPP4 due to the Q1020R mutation in the spike protein.
bioRxiv · Jun 17, 2025 · PreprintMicrobiology