Victor M. Corman

A century-old museum sample reveals abandavirus with modern day presence in northernEuropean bats

This study recovers an ancient Bandavirus genome from a 1919 bat sample and identifies its modern presence in European bats, showing its ability to block interferon induction.

A global serosurvey of RNA virus-reactive antibodies in bats and rodents reveals the enzootic presence of flavi- and paramyxoviruses in African Pteropodidae

This study uses serosurveys to detect RNA virus-reactive antibodies in bats and rodents, revealing high seroprevalence of flavi- and paramyxoviruses in African Pteropodidae.

Rewired type I IFN signaling is linked to age-dependent differences in COVID-19

This study identifies age-related rewiring of type I IFN signaling in immune cells linked to increased inflammation and altered antibody responses in COVID-19.

Q1020R in the spike proteins of MERS-CoV from Arabian camels and recent human cases confers resistance against soluble human DPP4

The paper compares MERS-CoV variants from Arabian and African camels, showing Arabian viruses are more resistant to inhibition by human soluble DPP4 due to the Q1020R mutation in the spike protein.

Ongoing evolution of Middle East Respiratory Syndrome Coronavirus, Kingdom of Saudi Arabia, 2023-2024

The study analyzes MERS-CoV genetic diversity in Saudi Arabian dromedary camels and humans, identifying new variants with unique Spike protein polymorphisms.

MPXV Infects Human PBMCs in a Type I Interferon-Sensitive Manner

This paper shows that MPXV infects human PBMCs in a type I interferon-sensitive manner, with monocytes, cycling NK cells, and regulatory CD4+ T-cells as susceptible cell types.

Comparative Analysis of SARS-CoV-2 Antigenicity across Assays and in Human and Animal Model Sera

The paper compares SARS-CoV-2 antigenicity across assays and in human and animal model sera, finding similar immunodominance patterns and antigenic maps but differences in titer magnitude and assay-specific fold change.

Gut microbiota dysbiosis is associated with altered tryptophan metabolism and dysregulated inflammatory response in severe COVID-19

This study links gut microbiota dysbiosis and altered tryptophan metabolism to increased inflammation in severe COVID-19 patients.

Genetic variability, including gene duplication and deletion, in early sequences from the 2022 European monkeypox outbreak

The paper analyzes genome sequences from the 2022 European monkeypox outbreak to identify genetic variability, including gene duplication and deletion, and their potential role in viral adaptation.

Topologically Engineered Tetrahedral Antibody Architectures for Multispecific Therapy

This paper engineers tetrahedral antibodies with a non-planar architecture to overcome steric constraints in multispecific therapy, showing improved stability and in vivo efficacy in non-human primates.

Transcriptomic responses of the human kidney to acute injury at single cell resolution

This study uses single-nuclei transcriptomics to analyze human kidney injury responses, identifying four injury-associated cell states and showing similar gene expression changes between AKI patients with and without COVID-19.

Olfactory transmucosal SARS-CoV-2 invasion as port of Central Nervous System entry in COVID-19 patients

The paper investigates SARS-CoV-2 entry into the CNS via the olfactory mucosa in COVID-19 patients and demonstrates neurotropism and cerebral thromboembolism.