Author

Michael Winkler

German Primate CenterORCID 0000-0002-6198-554XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:metagenomics· 1 Organism:mouse· 1

Frequent Co-Authors

Stefan PöhlmanniD· 5 shared Markus HoffmanniD· 4 shared Sabine Gärtner· 3 shared Heike Hofmann-Winkler· 2 shared Pamela Stomberg· 2 shared Prerna AroraiD· 2 shared Stephan LudwigiD· 2 shared Amy Madeleine Kempf· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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5 shared papersMicrobiology

Stefan PöhlmannORCID

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5 papers

Recent·Most cited

Development of immortalized Callithrix jacchus kidney cell lines supporting infection with a panel of viruses

Sabine Gärtner, Pamela Stomberg, Stefan Pöhlmann, Michael Winkler

The paper develops and characterizes three immortalized kidney cell lines from common marmosets that support infection with multiple viruses, including Zika and Herpes simplex virus 1.

PLoS ONE · Mar 2, 2026Peer-reviewedMicrobiology

Proteolytic processing of the Marburg virus glycoprotein depends on Sec616β and is required for cell entry

Katharina E. Decker, Anke Werner, Markus Hoffmann, Heike Hofmann-Winkler, Qi-Yin Chen, Lu Zhang, Pamela Stomberg, Sabine Gärtner, Amy Madeleine Kempf, Inga Nehlmeier, Hendrik Luesch, Torsten Steinmetzer, Eva Böttcher‐Friebertshäuser, Nabil Georges Seidah, Stefan Pöhlmann, Michael Winkler

This paper identifies Sec61β as essential for proteolytic processing and cell entry of Marburg virus glycoprotein, unlike Ebola virus, and suggests Sec61 as a therapeutic target.

bioRxiv · Jun 26, 2025 · PreprintMicrobiology

Q1020R in the spike proteins of MERS-CoV from Arabian camels and recent human cases confers resistance against soluble human DPP4

Nianzhen Chen, Hannah Kleine‐Weber, Khaled Riyad Alkharsah, Michael Winkler, Asisa Volz, Marcel A. Müller, Victor M. Corman, Christian Drosten, Markus Hoffmann, Stefan Pöhlmann

The paper compares MERS-CoV variants from Arabian and African camels, showing Arabian viruses are more resistant to inhibition by human soluble DPP4 due to the Q1020R mutation in the spike protein.

bioRxiv · Jun 17, 2025 · PreprintMicrobiology

Interferon induction and not replication interference mainly determines anti-influenza virus activity of defective interfering particles

Prerna Arora, Najat Bdeir, Sabine Gärtner, Stefanie Reiter, Lars Pelz, Ulrike Felgenhauer, Udo Reichl, Stephan Ludwig, Friedemann Weber, Markus Hoffmann, Michael Winkler, Stefan Pöhlmann

This study shows that defective interfering particles (DIPs) primarily exert antiviral activity through interferon (IFN) system activation rather than suppression of viral replication.

bioRxiv · Sep 20, 2021 · PreprintMolecular Biology

Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity

Markus Hoffmann, Heike Hofmann-Winkler, Joan C. Smith, Nadine Krüger, Prerna Arora, Lambert K. Sørensen, Ole Schmeltz Søgaard, Jørgen Bo Hasselstrøm, Michael Winkler, Tim Hempel, Lluı́s Raich, Simon Olsson, Olga Danov, Danny David Jonigk, Takashi Yamazoe, , Stefan Pöhlmann

This study shows camostat mesylate inhibits SARS-CoV-2 by blocking TMPRSS2 and its metabolite GBPA also has antiviral activity, suggesting no resistance through TMPRSS2-related proteases.

EBioMedicine · Mar 1, 2021Peer-reviewedMolecular Biology