Rapid femtosecond laser trenching accelerates cryo-electron tomography lamella workflows
Christian M. Orr, Pranav N. M. Shah, Éilís C. Bragginton, Saikat Chakraborty, Helen M. E. Duyvesteyn, Stephen Riggs, David Ian Stuart, Armin Wagner
This paper introduces a method using femtosecond laser trenching to speed up cryo-electron tomography lamella preparation by reducing milling time and damage.
bioRxiv · Oct 25, 2026 · PreprintBiophysics