Cancer BiologybioRxivPreprint
Clonal Heterogeneity in Human Pancreatic Ductal Adenocarcinoma and Its Impact on Tumor Progression
Despoina Kalfakakou, Daniel C. Cameron, Emily A. Kawaler…·Diane M. Simeone
This study analyzes clonal heterogeneity in human pancreatic ductal adenocarcinoma using single-cell and spatial transcriptomics, revealing transcriptional continua, clonal transitions, and spatially dispersed clones associated with metastasis.