Author

Diane M. Simeone

UC San Diego Health SystemORCID 0000-0001-5142-3087Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Lidong WangiD· 2 shared Adriana HeguyiD· 1 shared Aikaterini ZiogouiD· 1 shared Alec J. VaughaniD· 1 shared Amanda AckermanniD· 1 shared Amanda W. LundiD· 1 shared Andrew D. RhimiD· 1 shared Aristotelis TsirigosiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

Lidong WangORCID

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3 papers

Recent·Most cited

Cancer BiologyNaturePeer-reviewedNov 5, 2025

✦ In-depth digest

Targeting FSP1 triggers ferroptosis in lung cancer

Katherine Wu, Alec J. Vaughan, Jozef P. Bossowski…·Thales Y. Papagiannakopoulos

Genetic deletion or pharmacological inhibition of ferroptosis suppressor protein 1 (FSP1) induces lipid peroxidation and restricts lung adenocarcinoma growth in vivo, establishing FSP1 as a therapeutic vulnerability.

93 citationstop 1%

mousehuman

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Cancer BiologybioRxivPreprintFeb 11, 2025

Clonal Heterogeneity in Human Pancreatic Ductal Adenocarcinoma and Its Impact on Tumor Progression

Despoina Kalfakakou, Daniel C. Cameron, Emily A. Kawaler…·Diane M. Simeone

This study analyzes clonal heterogeneity in human pancreatic ductal adenocarcinoma using single-cell and spatial transcriptomics, revealing transcriptional continua, clonal transitions, and spatially dispersed clones associated with metastasis.

5 citations

humanscRNA-seq

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GenomicsbioRxivPreprintMar 28, 2021

Ultra-low Input Circulating Tumor DNA Detection by MED-Amp in Early-Stage Pancreatic Cancer

Erica D. Pratt, David Bing Zhen, Robert W. Cowan…·Andrew D. Rhim

This study evaluates the diagnostic sensitivity of the MED-Amp assay for detecting rare KRAS mutations in ctDNA from localized pancreatic cancer patients, showing improved detection at low DNA input and correlation with survival outcomes.

1 citation

humanDNA methylation

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