Ablation of telomerase reverse transcriptase in Leishmania major results in a senescent-like phenotype and loss of infectivity
Mark Ewusi Shiburah, Beatriz C. D. de Oliveira, Habtye Bisetegn, Débora Andrade-Silva, Luiz H. C. Assis, Rubem F. S. Menna‐Barreto, Marcos Meuser Batista, Maria de Nazaré Correia Soeiro, Benedito Donizete Menozzi, Hélio Langoni, Juliana Ide Aoki, Adriano Coelho, Maria Isabel Nogueira Cano
This study shows that deleting TERT in Leishmania major causes senescent-like traits and reduced infectivity, suggesting it as a potential drug target.
bioRxiv · Nov 10, 2023 · PreprintMolecular Biology