Adriano C. Coelho

This study identifies AQP1 in L. amazonensis as a glycosomal protein critical for iron homeostasis, osmoregulation, and antimony susceptibility, with distinct roles compared to other Leishmania species.

This paper identifies and validates cell-permeable inhibitors of Leishmania mexicana CLK1 using a BRET-based assay, showing WZ8040 effectively targets CLK1 with minimal host toxicity.

This study investigates the role of Leishmania major telomerase RNA (LeishTER) by generating knockout parasites, showing reduced proliferation, telomere shortening, and decreased infectivity.

This study shows that deleting TERT in Leishmania major causes senescent-like traits and reduced infectivity, suggesting it as a potential drug target.