José M.P. Freije

This paper introduces FAβ-gal, a fluorescence-based method to quantify SA-β-gal activity using X-gal, improving accuracy and sensitivity over traditional colorimetric assays.

This study shows that miR-29 is essential for adult cardiomyocyte function, as its deficiency leads to dilated cardiomyopathy and mitochondrial dysfunction in mice and human cells.

This study shows that loss of ATG4B, ATG4C, and ATG4D in mice causes systemic autophagy defects, leading to accelerated aging and shortened lifespan.