Mar Rodríguez-Santamaría

This study establishes patient-derived organoids from HNSCC tumors that recapitulate histological, molecular, and therapeutic diversity, enabling personalized therapeutic testing.

The paper shows that environmental enrichment modulates age-related changes in the 3D chromatin interactome of mouse hippocampal neurons, inducing maturation in young mice and partial rejuvenation in old mice.

This study shows that loss of ATG4B, ATG4C, and ATG4D in mice causes systemic autophagy defects, leading to accelerated aging and shortened lifespan.