Carlos López-Otı́n

This study shows that miR-29 is essential for adult cardiomyocyte function, as its deficiency leads to dilated cardiomyopathy and mitochondrial dysfunction in mice and human cells.

This study identifies molecular signatures of aging in the mouse brain through proteo-transcriptomic analysis, revealing changes in protein aggregation, mRNA relocalization, and translation efficiency linked to neurodegeneration.

This study shows that loss of ATG4B, ATG4C, and ATG4D in mice causes systemic autophagy defects, leading to accelerated aging and shortened lifespan.

This study identifies miR-29a-3p as a myokine secreted during resistance exercise that coordinates metabolic responses and miRNA expression in muscle and liver.