Jordan W. Raff

The paper demonstrates that recruiting a single protein to synthetic beads can seed the self-assembly of centrosome-like particles in Drosophila embryos.

This study investigates the structural differences in mitotic-centrosome assembly between Drosophila and C. elegans, showing divergent mechanisms involving Cnn and SPD-5 proteins.

The paper shows that Spd-2 recruits Polo and Aurora A to form two distinct scaffolds, Cnn-scaffold and TACC-scaffold, which are essential for mitotic centrosome assembly in Drosophila.