Author

Simon Guignard

Saint Louis UniversityORCID 0000-0002-9560-0046Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Pathology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Silvia González-NievesiD· 3 shared Vincenza CifarelliiD· 3 shared Anastasiia Vinogradskaia· 1 shared Anutosh ChakrabortyiD· 1 shared David DeBruiniD· 1 shared E C EbertiD· 1 shared Michelle BrennaniD· 1 shared Molee ChakrabortyiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersSystems Biology

Silvia González-NievesORCID

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Author profile →

3 papers

Recent·Most cited

Computational modeling of VEGF-A signaling predicts lymphatic junction state

Yiping Jia, Silvia González-Nieves, Simon Guignard, Vincenza Cifarelli, Stacey D. Finley

The paper develops a computational model of VEGF-A signaling in lymphatic endothelial cells to predict junction state transitions and shows how obesity affects these dynamics in different LEC populations.

bioRxiv · Oct 16, 2026 · PreprintSystems Biology

Loss of E3 ligase Ube4A disrupts colon homeostasis and accelerates experimental colitis via altered lipid handling

Simon Guignard, Molee Chakraborty, Silvia González-Nieves, David DeBruin, E C Ebert, Anastasiia Vinogradskaia, Michelle Brennan, Ryan M. Teague, Anutosh Chakraborty, Vincenza Cifarelli

This study shows that loss of Ube4A in mice worsens experimental colitis by disrupting lipid metabolism and increasing inflammation.

bioRxiv · Jan 3, 2026 · PreprintPathology

Cross-family Signaling: PDGF Mediates VEGFR Activation and Endothelial Function

Xinming Liu, Yingye Fang, Shreya Karra, Silvia González-Nieves, Simon Guignard, Vincenza Cifarelli, P.I. Imoukhuede

This study shows PDGFs activate VEGFRs and downstream pathways in endothelial cells, enhancing proliferation and migration, revealing cross-family signaling in angiogenesis.

bioRxiv · Feb 27, 2025 · PreprintBioengineering