Author

Rafael Sobrano Fais

National Jewish HealthORCID 0000-0002-4715-7318Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Organism:rat· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Andrea L. FrumpiD· 2 shared Avram D. WaltsiD· 2 shared Sébastien BonnetiD· 2 shared Tim LahmiD· 2 shared Alice Bourgeois· 1 shared Amanda Fisher· 1 shared Bakhtiyor Yakubov· 1 shared Brenda M. OgleiD· 1 shared

Activity by Year

2026-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

Andrea L. FrumpORCID

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3 papers

Recent·Most cited

Cell BiologyAmerican Journal of Respiratory Cell and Molecular BiologyPeer-reviewedSep 4, 2026

17β-Estradiol Promotes Right Ventricle Angiogenesis via Estrogen Receptor α and Apelin Signaling

Simon Bousseau, Andrea L. Frump, Avram D. Walts…·Tim Lahm

This study shows that 17β-estradiol promotes right ventricle angiogenesis through estrogen receptor α and apelin signaling in pulmonary hypertension.

DOI 10.1093/ajrcmb/aanag177

𝕏 PostBluesky

Pharmacology & ToxicologyBiomoleculesPeer-reviewedMar 13, 2026

A KCa 2.2/2.3 Opener Reverses ET-1-induced NLRP3 Activation in Hypertensive Mice Corpora Cavernosa

Rafael Sobrano Fais, Simón Comerma-Steffensen, Estéfano Pinilla…·Ulf Simonsen

This study shows that activating KCa 2.2/2.3 channels reverses ET-1-induced NLRP3 activation and erectile dysfunction in hypertensive mice.

3 citationstop 4%

mouseexperimental assay

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Molecular BiologybioRxivPreprintFeb 14, 2026

Cardiomyocyte NLRP3 signaling in right heart failure is sexually dimorphic via estrogen receptor α

Rafael Sobrano Fais, Erica Das Neves Palotta, Katrina W. Kopf…·Tim Lahm

This study identifies a sexually dimorphic NLRP3 signaling pathway in right ventricular failure, showing estrogen receptor α mediates protection against NLRP3-induced contractile dysfunction in cardiomyocytes.

1 citation

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