The paper identifies a mechanism by which REP/CAP contaminants arise in rAAV gene therapy through P5 promoter-mediated incorporation during manufacturing.

medRxiv · Sep 14, 2026 · PreprintGenetic & Genomic Medicine

Immune History Modifies Disease Severity to HPAI H5N1 Clade 2.3.4.4b Viral Challenge

Pamela H. Brigleb, Bridgett Sharp, Ericka Kirkpatrick Roubidoux, Victoria Meliopoulos, Shaoyuan Tan, Brandi Livingston, Dorothea R. Morris, Tyler J. Ripperger, Lauren Lazure, Velmurugan Balaraman, Alexis C. Thompson, Katie E. Kleinhenz, Kiril M. Dimitrov, Paul Glyndwr Thomas, Stacey Schultz‐Cherry

The paper shows that pre-existing immunity from H1N1 infection or vaccination can protect against lethal HPAI H5N1 clade 2.3.4.4b challenge in mice and ferrets, independent of hemagglutination inhibition titers.

bioRxiv · Oct 23, 2024 · PreprintMicrobiology

Effects of Oral Exposure to HPAI H5N1 Pasteurized in Milk on Immune Response and Mortality in Mice

Pamela H. Brigleb, Ericka Kirkpatrick Roubidoux, Brandi Livingston, Bridgett Sharp, Victoria A. Meliopoulos, Shaoyuan Tan, Dorothea R. Morris, Lauren Lazure, Stacey Schultz‐Cherry

This study investigates the effects of oral exposure to pasteurized HPAI H5N1 virus in milk on immune response and mortality in mice, finding limited health risk and no prevention of immune-mediated protection.

bioRxiv · Oct 3, 2024 · PreprintMicrobiology

Detection and Phylogenetic Analysis of Highly Pathogenic A/H5N1 Avian Influenza Clade 2.3.4.4b Virus in Chile, 2022

Pedro Jiménez-Bluhm, Jurre Y. Siegers, Shaoyuan Tan, Bridgett Sharp, Pamela J. Freiden, Magdalena Johow, Katherinne Orozco, Soledad Ruíz, Cecilia Baumberger, Pablo Galdames, María Antonieta González, Camila Rojas, Erik A. Karlsson, Christopher Hamilton-West M, Stacey Schultz‐Cherry

The paper reports the detection of H5N1 AIV clade 2.3.4.4b in Chile in 2022, linked to migratory birds and showing phylogenetic similarity to Peruvian isolates.

Emerging Microbes & Infections · May 31, 2023Peer-reviewedGenetics