Author

Cassandra M. Leech

University of Wisconsin–MadisonORCID 0000-0002-4741-9568Unclaimed ORCID profile · follow to get notified of new preprints

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Biochemistry· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

John M. DenuiD· 1 shared Spencer A. HawsiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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2 top collaborators · 1 mutual co-author link

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1 shared paperBiochemistry

John M. DenuORCID

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1 paper

Recent·Most cited

Methionine, Not S-adenosylmethionine, Acts as a Primary Metabolic Stress Signal for Chromatin Remodeling

Cassandra M. Leech, Spencer A. Haws, John M. Denu

The paper shows methionine, not SAM, is the primary metabolic signal for chromatin remodeling under stress, with methionine depletion causing epigenetic and transcriptional changes independent of SAM levels.

bioRxiv · May 5, 2026 · PreprintBiochemistry