Author

Sydney B. Blattman

Columbia UniversityORCID 0000-0002-4758-8775Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Microbiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:scRNA-seq· 2 Research Focus:trajectory inference· 2 Organism:bacteria (other)· 1 Research Focus:clustering· 1

Frequent Co-Authors

Panos OikonomouiD· 2 shared Saeed TavazoieiD· 2 shared Wenyan JiangiD· 2 shared Andrew S. Kohlway· 1 shared Austin VarelaiD· 1 shared Benan N. NalbantiD· 1 shared Brooke E. HowittiD· 1 shared Caleb A. LareauiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersMicrobiology

Panos OikonomouORCID

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3 papers

Recent·Most cited

Scalable genotyping in fixed transcriptomes resolves clonal heterogeneity via single-cell sequencing

Sydney B. Blattman, Nabih Maslah, Austin Varela, Karolis Kumpaitis, Benan N. Nalbant, Catherine Snopkowski, Marisa Mariani, Laura C. Kida, Meril T. Takizawa, Nalin Ratnayeke, Kenny Kwok Hei Yu, Sunjay Fernandes, Nima Mousavi, Erik Borgström, Derek Vallejo, , Caleb A. Lareau

GIFT enables high-accuracy genotyping in single cells, revealing mutation-dependent hematopoietic responses in MPN patients.

bioRxiv · Jul 3, 2026 · PreprintGenomics

The genetic landscape of antibiotic sensitivity in Staphylococcus aureus

Li Wan, Menghan Liu, Panos Oikonomou, Sydney B. Blattman, Mirela Berisa, Falguni Paul, Julia Hettleman, Joseph Gonzalez, Qiaoyu Hu, Howe Chen, Saeed Tavazoie, Wenyan Jiang

This study identifies gene-drug and gene-gene interactions in Staphylococcus aureus using CRISPR-interference, revealing vulnerabilities for new drug targets and combination therapies.

Science Advances · May 8, 2026Peer-reviewedMicrobiology

Prokaryotic Single-Cell RNA Sequencing by In Situ Combinatorial Indexing

Sydney B. Blattman, Wenyan Jiang, Panos Oikonomou, Saeed Tavazoie

PETRI-seq enables single-cell RNA sequencing of prokaryotes by overcoming technical barriers, revealing growth phase-specific cell states and prophage induction in S. aureus.

Nature Microbiology · May 25, 2020Peer-reviewedSystems Biology