Kenny Kwok Hei Yu

This study shows that the antibody 1H5 targets activated ADAM10 to suppress NOTCH-driven glioma progenitors, reducing tumor growth and improving survival in xenograft models.

GIFT enables high-accuracy genotyping in single cells, revealing mutation-dependent hematopoietic responses in MPN patients.

ALARMIST identifies multicellular communication motifs in spatial transcriptomics data, revealing microenvironmental drivers of tumor progression in lung and brain cancers.

The paper analyzes the evolutionary trajectories of high-level copy-number amplifications in cancer cell genomes to distinguish between extrachromosomal and intrachromosomal amplification mechanisms.

This study shows how cancer cell stiffness, influenced by environmental rigidity, affects immune response and metastatic site selection in mice and patients.

This study identifies a pathogenic subpopulation of glioma-associated macrophages (mGAMs) linked to glioma progression through GRN analysis and functional validation.

This paper introduces PERFF-seq, a method to profile rare cell states via scRNA-seq by enriching for specific RNA transcripts, demonstrating its application in immune and brain tissues.