Overcoming Cisplatin Resistance in 3D Oral Squamous Cell Carcinoma Models via Nanoparticle-Mediated Pt(IV) Drug Delivery.
Ana Belén Griso-Acevedo, Francisco Navas, Natalia L. Calvo, Victoria Morales, Beatriz Castelo, Javier Gonzalez, María José Morán Soto, Raúl Sanz, José Luis Cebrián-Carretero, Rafael A. García‐Muñoz, Ana Sastre-Perona
This study evaluates Pt(IV)-based prodrug delivery via mesoporous silica nanoparticles in 3D oral squamous cell carcinoma models, showing improved cytotoxicity and apoptotic effects compared to cisplatin.
bioRxiv · Feb 23, 2026 · PreprintCancer Biology