Cancer BiologyCell chemical biologyPeer-reviewed
Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking
Kelly H Sokol, Cameron J. Lee, Thomas J. Rogers…·Evan C. Lien
The paper shows lipid-starved cancer cells are more sensitive to ferroptosis due to increased PUFA trafficking into phospholipids, challenging the assumption that PUFA levels directly determine ferroptosis susceptibility.
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