Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking
Kelly H Sokol, Cameron J. Lee, Thomas J. Rogers, Althea N. Waldhart, Abigail E. Ellis, Sahithi Madireddy, Samuel R. Daniels, Rachel J. House, Xinyu Ye, Mary Olesnavich, Amy Johnson, Benjamin R. Furness, Ryan D. Sheldon, Evan C. Lien
The paper shows lipid-starved cancer cells are more sensitive to ferroptosis due to increased PUFA trafficking into phospholipids, challenging the assumption that PUFA levels directly determine ferroptosis susceptibility.
Cell chemical biology · Oct 22, 2024Peer-reviewedCancer Biology