An alternative route for β-hydroxybutyrate metabolism supports fatty acid synthesis in cancer cells
Faith C Kaluba, Thomas J. Rogers, Yu‐Jin Jeong, Rachel J. House, Althea N. Waldhart, Kelly H Sokol, Samuel R. Daniels, Cameron J. Lee, Joseph Longo, Amy Johnson, Vincent J Sartori, Ryan D. Sheldon, Russell G. Jones, Evan C. Lien
This study identifies a non-canonical metabolic pathway in cancer cells that uses β-hydroxybutyrate for fatty acid synthesis, supporting tumor growth under lipid-limited conditions.
Nature Metabolism · Sep 8, 2025Peer-reviewedCancer Biology