Kelly H Sokol

This study identifies a non-canonical metabolic pathway in cancer cells that uses β-hydroxybutyrate for fatty acid synthesis, supporting tumor growth under lipid-limited conditions.

The paper shows that arginine restriction in the tumor microenvironment limits lipid synthesis in pancreatic cancers, making them susceptible to polyunsaturated fatty acids via ferroptosis.

The paper shows lipid-starved cancer cells are more sensitive to ferroptosis due to increased PUFA trafficking into phospholipids, challenging the assumption that PUFA levels directly determine ferroptosis susceptibility.