HuR-Driven Reversible Mitochondrial Shuttling Buffers Cytosolic miRNA Levels in Hepatic Cells
Saikat Banerjee, Sourav Hom Choudhury, Susanta Chatterjee, Guoku Hu, Kamalika Mukherjee, Suvendra N. Bhattacharyya
The paper shows that specific miRNAs, including miR-122, are reversibly shuttled to mitochondria in stressed hepatic cells, where they regulate apoptosis-related gene expression and cytosolic miRNA levels.
bioRxiv · Apr 8, 2025 · PreprintCell Biology