Alexandra Naba

MatriSpace identifies and visualizes spatial ECM gene expression patterns in health and disease using spatial transcriptomics data.

This study shows that SNED1 interacts with LDV-binding integrins to remodel the ECM, align cells, and promote proliferation, crucial for neural crest migration and cancer invasion.

This study compares the extracellular matrix composition of the human omentum and mesentery using proteomics to identify potential factors contributing to ovarian cancer metastasis.

This study shows how fibronectin composition and TG2 cross-linking affect ovarian cancer cell adhesion in ECM-like constructs.

This study identifies ECM protein signatures in PDAC that correlate with CD8+ T-cell infiltration and patient survival.

MatriCom mines scRNA-Seq datasets to infer ECM-ECM and cell-ECM communication systems across diverse cell populations.

This paper introduces a time-lapse proteomic method to improve ECM protein sequence coverage and identify differential trypsin susceptibility.

This study identifies SNED1 as an ECM protein that promotes cell adhesion in breast cancer and neural crest cells through interactions with integrins α5β1 and αvβ3.

Matrisome AnalyzeR provides tools to annotate and quantify extracellular matrix molecules in large datasets across organisms.

This study shows that Sned1 knockout in mice causes early neonatal death and craniofacial defects, highlighting its essential role in development.