Dharma Pally

This study shows that SNED1 interacts with LDV-binding integrins to remodel the ECM, align cells, and promote proliferation, crucial for neural crest migration and cancer invasion.

This study compares the extracellular matrix composition of the human omentum and mesentery using proteomics to identify potential factors contributing to ovarian cancer metastasis.

This study identifies ECM protein signatures in PDAC that correlate with CD8+ T-cell infiltration and patient survival.

This study identifies LOX as a key mediator of TGF-β-induced myCAF state in breast cancer, showing its role in promoting tumor growth through a LOX/FAK/GSK3β/β-catenin pathway.

This study identifies SNED1 as an ECM protein that promotes cell adhesion in breast cancer and neural crest cells through interactions with integrins α5β1 and αvβ3.

The paper analyzes N-linked glycosylation sites in human glycoproteins and finds they are more prevalent in ordered regions than disordered regions, suggesting a functional trade-off between protein stability and flexibility.