Lawrence B. Cohen

Synaptic and Somatic Targeting of ArcLight, a Genetically Encoded Voltage Indicator

This study evaluates subcellular targeting of ArcLight, a GEVI, using different targeting sequences to enhance signal localization without affecting voltage sensitivity.

The olfactory bulb carries out concentration invariance calculations by itself and does it very quickly.

The paper shows that the olfactory bulb performs concentration invariance computations independently and rapidly without relying on feedback from other brain regions.

Voltage imaging using transgenic mouse lines expressing the GEVI ArcLight in two olfactory cell types

This study develops and validates transgenic mouse lines expressing the GEVI ArcLight in specific olfactory cell types for in vivo voltage imaging of odorant responses.

The olfactory bulb contributes to the adaptation of odor responses: the input-output transformation

The paper investigates whether the olfactory bulb contributes to odor response adaptation by comparing input and output signals in the olfactory bulb during repeated odor stimulation.

Conserved amino acids residing outside the voltage field can shift the voltage sensitivity and increase the signal size of Ciona based GEVIs

The paper identifies conserved polar residues in the voltage-sensing domain of Ciona-based GEVIs that, when mutated, shift voltage sensitivity and increase signal size.