Spencer J Gray

Declaration of Fermentation: Community-Embedded Wild Yeast Bioprospecting as a Model for Place-Based CURE Design

The paper presents a place-based CURE model where students isolate and deploy wild yeast, confirming its identity and partnering with local breweries to create a historical ale, with sensory validation and design principles outlined.

Genome-wide mapping of helicase-generated ssDNA reveals Hrq1 activity at RNA polymerase III-transcribed genes

The paper maps helicase activity genome-wide using AID-mediated mutational footprints, revealing Hrq1's association with RNA polymerase III-transcribed genes.

Genome-scale characterization of wild yeasts reveals cryptic diversity and population structure across three genera

This study uses genome-scale sequencing to reveal hidden diversity and population structure in wild yeasts, uncovering mixed cultures, a rare species, and a new population while showing that some apparent gene flow signals are artifacts.

FIDDL: depth-matched negative controls distinguish genuine interspecific introgression from competitive-mapping artifact

The paper introduces FIDDL, a tool to distinguish genuine interspecific introgression from artifacts by using depth-matched negative controls and locus-level tests.

A genetically buffered helicase network promotes tolerance of G-quadruplex stabilization in Saccharomyces cerevisiae

This paper investigates G-quadruplex tolerance in yeast by testing helicase mutants, finding that redundancy across multiple helicases, not single families, is required for G4 resolution.

Dimerization of Cdc13 is essential for dynamic DNA exchange on telomeric DNA

This paper shows that Cdc13 dimerization is required for dynamic DNA exchange on telomeres, using biochemical assays and mutants.