Timothy J. Eisen

This study shows LAT condensation gates PLCγ1 activation through bimodal LAT phosphorylation, enhancing signal amplification and noise suppression in T cells.

The paper measures how costimulatory and inhibitory signals affect LAT condensate nucleation timing after TCR activation.

The paper assesses BTK autoinhibition by substituting SH2 domains and finding that some substitutions enhance fitness by disrupting autoinhibition while maintaining phosphotyrosine targeting.

This study shows that Grb2 enhances PIP3-bound Btk activity on membranes by recruiting it to scaffold-mediated signaling clusters.

The paper examines mRNA metabolism dynamics in mouse fibroblasts, finding that deadenylation rates determine cytoplasmic mRNA stability and degradation.

The paper shows miRNAs accelerate decay of short-tailed target mRNAs, preventing their accumulation despite promoting deadenylation.