Author

Sam Ghaffari-Kashani

QB3ORCID 0009-0001-0711-6562Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Angela M. PhillipsiD· 1 shared Anthony KhalifehiD· 1 shared Chien‐Lun HungiD· 1 shared Claudio CatalanoiD· 1 shared Cole R Tharp· 1 shared Giovanna ScapiniD· 1 shared Gyunghoon KangiD· 1 shared Jay T. GrovesiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperEvolutionary Biology

Angela M. PhillipsORCID

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2 papers

Recent·Most cited

Evolutionary BiologybioRxivPreprintMar 17, 2026

Biophysical trade-offs in antibody evolution are resolved by conformation-mediated epistasis

Cole R Tharp, Claudio Catalano, Anthony Khalifeh…·Angela M. Phillips

This study quantifies biophysical trade-offs in antibody evolution by analyzing surface expression, affinity, and self-reactivity across 213 evolutionary intermediates of a SARS-CoV-2 antibody lineage.

5 citations

humanproteomics

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BiochemistrybioRxivPreprintFeb 6, 2025

BTK Autoinhibition Analyzed by High-Throughput SH2 Domain Swaps

Timothy J. Eisen, Sam Ghaffari-Kashani, Chien‐Lun Hung…·John Kuriyan

The paper assesses BTK autoinhibition by substituting SH2 domains and finding that some substitutions enhance fitness by disrupting autoinhibition while maintaining phosphotyrosine targeting.

1 citation

experimental assay

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