Enhancer Placement Impacts Transcriptional Dynamics in Drosophila Embryos
Emilia A. Leyes Porello, Jiayi Wu, Samantha Fallacaro, Emma Dreispiel Juan, Robert T. Trudeau, J. Andres Vidal, Shufan Lin, Cesar Nieto, Abhyudai Singh, Mustafa Mir, Bomyi Lim
This study shows that enhancer-promoter configurations in Drosophila embryos affect transcriptional dynamics, with downstream enhancer positioning reducing mRNA output by 70%.
Nature Communications · May 7, 2026Peer-reviewedMolecular Biology