Author

Emilia A. Leyes Porello

University of PennsylvaniaORCID 0000-0002-2917-3883Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Bomyi LimiD· 3 shared Abhyudai SinghiD· 1 shared Cesar NietoiD· 1 shared Da Kuang· 1 shared Daeyeon LeeiD· 1 shared Emma Dreispiel JuaniD· 1 shared Gaochen JiniD· 1 shared Hyejoong JeongiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMolecular Biology

Bomyi LimORCID

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3 papers

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedMay 7, 2026

Enhancer Placement Impacts Transcriptional Dynamics in Drosophila Embryos

Emilia A. Leyes Porello, Jiayi Wu, Samantha Fallacaro…·Bomyi Lim

This study shows that enhancer-promoter configurations in Drosophila embryos affect transcriptional dynamics, with downstream enhancer positioning reducing mRNA output by 70%.

3 citationstop 3%

Drosophilaexperimental assay

𝕏 PostBluesky

BioengineeringSmallPeer-reviewedJun 16, 2025

SCO-pH: Microfluidic dynamic phenotyping platform for high-throughput screening of single cell acidification

Hyejoong Jeong, Emilia A. Leyes Porello, Jean G. Rosario…·Junhyong Kim

SCO-pH enables high-throughput single-cell acidification analysis by compartmentalizing cells in microfluidic droplets and measuring extracellular pH changes to distinguish metabolic states.

4 citations

experimental assaycell type annotation

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Molecular BiologybioRxivPreprintMar 17, 2025

Heterogeneous Sox2 transcriptional dynamics mediate pluripotency maintenance in mESCs in response to LIF signaling perturbations

Gaochen Jin, Emilia A. Leyes Porello, Jingchao Zhang, Bomyi Lim

This study investigates how LIF signaling perturbations affect Sox2 transcriptional dynamics in mESCs, revealing that reduced Sox2 expression, not complete loss, drives pluripotency loss.

1 citation

mousescRNA-seq

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