Samantha Fallacaro

The paper uses live-imaging and computational modeling to show that Dorsal hub formation in Drosophila embryos depends on TF-DNA binding kinetics, not enhancer sequence or higher-order regulatory structures.

This study shows that enhancer-promoter configurations in Drosophila embryos affect transcriptional dynamics, with downstream enhancer positioning reducing mRNA output by 70%.

The paper investigates RNAPII clustering during ZGA in Drosophila embryos, showing clusters are stably associated with active genes and reflect transcriptional activity, not phase separation.

The paper investigates how transcription factor hubs are localized to target genes through a kinetic balance of interactions in Drosophila embryos.