MicrobiologyPLoS PathogensPeer-reviewed
Structural Basis for Sarbecovirus Rc-o319 Spike Adaptation to Rhinolophus cornutus Bat ACE2 and Constraints on Switching to Human ACE2
Jingjing Wang, Zexuan Li, Yong Li Jiang…·Xiaoli Xiong
This study characterizes the Rc-o319 S-protein's adaptation to R. cornutus ACE2 and identifies structural constraints limiting its ability to bind human ACE2.
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