Hang Yuan

This study characterizes the Rc-o319 S-protein's adaptation to R. cornutus ACE2 and identifies structural constraints limiting its ability to bind human ACE2.

This study identifies structural features of affinity-matured R1-32-like antibodies that enable tolerance to SARS-CoV-2 mutations and reveals an ultrapotent antibody with broad variant activity.

The paper uses AI to identify convergent somatic hypermutation patterns in antibodies, enabling the discovery of variant-resilient broadly neutralizing antibodies from early-pandemic data.