Structural Basis for Sarbecovirus Rc-o319 Spike Adaptation to Rhinolophus cornutus Bat ACE2 and Constraints on Switching to Human ACE2
Jingjing Wang, Zexuan Li, Yong Li Jiang, Zimu Li, Hang Yuan, Chuanying Niu, Yifeng Teng, Banghui Liu, Mei Li, Min Zhou, Wenxiu Liu, Huimin Feng, Jing Chen, Jun He, Xinwen Chen, Xiaoli Xiong
This study characterizes the Rc-o319 S-protein's adaptation to R. cornutus ACE2 and identifies structural constraints limiting its ability to bind human ACE2.
PLoS Pathogens · May 21, 2026Peer-reviewedMicrobiology