Jun He

This study determines the structure of PEDV S1B bound by neutralizing and non-neutralizing antibodies, revealing how C62 targets a conserved epitope and influences viral entry and neutralization.

This study characterizes the Rc-o319 S-protein's adaptation to R. cornutus ACE2 and identifies structural constraints limiting its ability to bind human ACE2.

This study reveals how the Rpd3L complex uses an asymmetric architecture to activate deacetylation in response to chromatin context.

This study identifies structural features of affinity-matured R1-32-like antibodies that enable tolerance to SARS-CoV-2 mutations and reveals an ultrapotent antibody with broad variant activity.

This study resolves the structural mechanism of ncBAF-nucleosome interaction, showing BCL7B's role in chromatin remodeling and its connection to nuclear actin networks.

This study identifies Munc13-4 as a regulator of exosomal PD-L1 sorting and secretion, showing its role in tumor immune evasion and potential as a therapeutic target.