Tatsuo Shibata

Kalman-filter Force Inference: an estimation framework for cellular forces from temporal evolution of epithelial morphogenesis

This paper introduces Kalman-filter Force Inference (KFI) to estimate cellular forces from time-lapse imaging of epithelial deformation, without assuming static force balance.

Force transmission balance through adhesions determines multicellular handedness

The paper shows multicellular handedness depends on force transmission balance through adhesions, not single-cell chirality, using human epithelial cells and modeling.

Circumferential actomyosin bundles drive endothelial cell deformations to constrict blood vessels

This study identifies circumferential actomyosin bundles as drivers of endothelial cell deformations that regulate vessel diameter and prevent vascular malformations.

Migrating mesoderm cells self-organize into a dynamic meshwork structure during chick gastrulation

The paper shows mesoderm cells form a dynamic meshwork during chick gastrulation, supported by N-cadherin adhesion, which facilitates collective migration.

Mesenchymal-Epithelial Transition Regulates Initiation of Pluripotency Exit before Gastrulation

The paper shows that pluripotent stem cells undergo a mesenchymal-epithelial transition (MET) before losing pluripotency, which is distinct from the gastrulation EMT and regulated by integrin-mediated cell-matrix interactions.

Synthetic mammalian pattern formation driven by differential diffusivity of Nodal and Lefty

The paper demonstrates that a synthetic mammalian reaction-diffusion pattern can be generated using Nodal and Lefty proteins with differential diffusivity in cell culture.