Author

Jānis Leitāns

Latvian Biomedical Research and Study CentreORCID 0000-0002-4853-8147Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Andris KazāksiD· 2 shared Agnė Kvietkauskaitė· 1 shared Aivaras VaškevičiusiD· 1 shared Algirdas KaupinisiD· 1 shared Asta ZubrienėiD· 1 shared Audronė RukšėnaitėiD· 1 shared Aurelija MickevičiūtėiD· 1 shared Claudiu Trandafir SupuraniD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiophysics

Andris KazāksORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Targeted anticancer pre-vinylsulfone covalent inhibitors of carbonic anhydrase IX

Aivaras Vaškevičius, Denis Baronas, Jānis Leitāns, Agnė Kvietkauskaitė, Audronė Rukšėnaitė, Elena Manakova, Zigmantas Toleikis, Algirdas Kaupinis, Andris Kazāks, Marius Gedgaudas, Aurelija Mickevičiūtė, Vaida Juozapaitienė, Helgi B. Schiöth, Kristaps Jaudzems, Mindaugas Valius, , Daumantas Matulis

The paper designs and tests novel covalent inhibitors targeting CAIX, achieving high affinity and selectivity for cancer treatment.

eLife · Sep 26, 2024Peer-reviewedBiophysics

Structural basis of saccharine derivative inhibition of carbonic anhydrase IX

Jānis Leitāns, Andris Kazāks, Jānis Bogans, Claudiu Trandafir Supuran, Ināra Akopjana, Jekaterīna Ivanova, Raivis Žalubovskis, Kaspars Tārs

This study investigates the binding of saccharine derivatives to hCA IX using crystallography, revealing structural insights for designing selective inhibitors.

bioRxiv · Nov 1, 2023 · PreprintMolecular Biology