Mustafa Khammash

This study shows that dynamic pulsatile signals from a light-responsive transcription factor reduce gene expression variability and enable precise multi-gene regulation in yeast.

This paper proposes combining antithetic integral feedback with negative feedback to reduce variance in stochastic reaction networks, showing a trade-off between settling-time and variance.

This paper introduces an optogenetic platform for single-cell transcription control, achieving mRNA tunability and reduced variability in yeast cells.

The paper develops blue light-inducible T7 RNA polymerases for precise spatiotemporal control of gene expression in bacteria and other organisms.

This paper introduces a new regulatory motif called antithetic integral feedback that enables robust perfect adaptation in noisy biomolecular networks.