Dirk Benzinger

Predictable Engineering of Signal-DependentCis-Regulatory Elements

The paper develops a method to engineer synthetic cis-regulatory elements that control gene expression in response to signals, showing they can be designed using quantitative rules.

Illuminating morphogen and patterning dynamics with optogenetic control of morphogen production

This paper introduces an optogenetic system to control morphogen production and study patterning dynamics in vitro, revealing how Shh concentration and duration affect neural progenitor domain formation.

Synthetic gene networks recapitulate dynamic signal decoding and differential gene expression

The paper designs synthetic gene networks that decode dynamic signals into gene expression patterns, showing increased information transmission capacity through dynamic multiplexing.

Cell-in-the-loop pattern formation with optogenetically emulated cell-to-cell signaling

The paper introduces a cell-in-the-loop approach to synthetic biology pattern formation, demonstrating checkerboard patterning through optogenetic signaling emulated in silico.

Tuning gene expression variability and multi-gene regulation by dynamic transcription factor control

This study shows that dynamic pulsatile signals from a light-responsive transcription factor reduce gene expression variability and enable precise multi-gene regulation in yeast.

Optogenetic Single-Cell Control Of Transcription Achieves Mrna Tunability And Reduced Variability

This paper introduces an optogenetic platform for single-cell transcription control, achieving mRNA tunability and reduced variability in yeast cells.