Early-life exposure to commensal lung bacteria primes innate antiviral immunity and prevents RSV immunopathology in neonatal mice
Quentin Marquant, Claire Chottin, Cécile Ferret, Eloi Poucet, Vinciane Saint‐Criq, Daphné Laubreton, Carole Drajac, Edwige Bouguyon, Aude Rémot, Samuel Constant, Song Mei Huang, Édouard Sage, Isabelle Schwartz-Cornil, Muriel Thomas, Sabine Riffault, Delphyne Descamps
This study shows that early-life exposure to a specific lung bacterial strain reduces RSV immunopathology by enhancing antiviral immunity in neonatal mice and human airway models.
bioRxiv · Jul 1, 2026 · PreprintImmunology