Prominin-1 null Xenopus laevis develop subretinal drusenoid-like deposits, cone-rod dystrophy, and dysmorphic retinal pigment epithelium.
Brittany J. Carr, Dominic Skitsko, Linnea M. Kriese, Jun Liang Song, Zixuan Li, Myeong Jin Ju, Orson L. Moritz
This study shows that prom1-null Xenopus laevis develop subretinal drusenoid-like deposits and retinal degeneration, indicating RPE dysfunction precedes photoreceptor loss.
Journal of Cell Science · Oct 2, 2024Peer-reviewedCell Biology