Author

Danuta Sastre

SRI InternationalORCID 0000-0002-4917-4103Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Birgitt SchüleiD· 2 shared C. Alejandra Morato TorresiD· 2 shared Deniz KirikiD· 2 shared Faria ZafariD· 2 shared Lei S. QiiD· 2 shared De’Angelo HermeskyiD· 1 shared Desiree Piper· 1 shared Jocelyn Palafox Vazquez· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersNeuroscience

Birgitt SchüleORCID

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2 papers

Recent·Most cited

Robust nuclease-dead S. aureus dCas9-mediated alpha-synuclein knockdown in substantia nigra in a humanized mouse model of Parkinson's disease

C. Alejandra Morato Torres, Faria Zafar, Danuta Sastre, De’Angelo Hermesky, Max Yang Chen, Jocelyn Palafox Vazquez, Lei S. Qi, Deniz Kirik, Birgitt Schüle

This paper demonstrates that sadCas9-mediated CRISPRi reduces alpha-synuclein expression in a humanized mouse model of Parkinson's disease, showing long-term downregulation and attenuated immune response.

bioRxiv · Sep 5, 2023 · PreprintNeuroscience

Nuclease-dead S. aureus Cas9 downregulates alpha-synuclein and reduces mtDNA damage and oxidative stress levels in patient-derived stem cell model of Parkinson's disease

Danuta Sastre, Faria Zafar, C. Alejandra Morato Torres, Desiree Piper, Deniz Kirik, Laurie H. Sanders, Lei S. Qi, Birgitt Schüle

This study uses CRISPRi to downregulate alpha-synuclein in a Parkinson's disease patient-derived model, reducing oxidative stress and mtDNA damage.

bioRxiv · Jan 24, 2023 · PreprintNeuroscience