Author

Mische Holland

University of PittsburghORCID 0000-0002-4917-9211Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:chromatin & epigenetic regulation· 3 Research Focus:gene regulatory network inference· 3 Assay:whole-genome sequencing· 3 Approach:comparative / phylogenetic analysis· 2 Research Focus:development & morphogenesis· 2 Assay:DNA methylation· 2 Organism:Drosophila· 2 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

Tera C. LeviniD· 3 shared Elizabeth A. OstrowskiiD· 2 shared Sean McFadyeniD· 2 shared Arya KauliD· 1 shared Cathleen M.E. Broersma· 1 shared Célia SouqueiD· 1 shared Courtney MastersoniD· 1 shared Fabiola Medina· 1 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersEvolutionary Biology

Tera C. LevinORCID

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Author profile →

4 papers

Recent·Most cited

Hypermutable hotspot enables the rapid evolution of self/non-self recognition genes in Dictyostelium

Mische Holland, M.W. Ahmed, Janet M. Young, James R. Drurey, Sean McFadyen, Elizabeth A. Ostrowski, Tera C. Levin

The paper investigates the rapid evolution of self/non-self recognition genes in Dictyostelium by analyzing genome sequences and identifying a hypermutable hotspot in the tgrBC locus.

Proceedings of the National Academy of Sciences · Dec 16, 2025Peer-reviewedEvolutionary Biology

Evolutionary dynamics of the tgr gene family in Dictyostelium allows escape from Crozier's Paradox

Rafael Prieto, Sean McFadyen, Fabiola Medina, Mische Holland, Cathleen M.E. Broersma, Jenna Masterson, Courtney Masterson, Hui Hui Phua, Jennie J. Kuzdzal‐Fick, Murray P. Cox, Tera C. Levin, Elizabeth A. Ostrowski

The paper examines Crozier's Paradox in Dictyostelium discoideum by analyzing tgrB1 and tgrC1 genes, finding no strong evidence for the paradox and suggesting recombination generates genetic variation.

bioRxiv · Oct 22, 2025 · PreprintEvolutionary Biology

Genomic resistance in historical clinical isolates increased in frequency and mobility after the age of antibiotics

Arya Kaul, Célia Souque, Mische Holland, Michael Baym

This study analyzes historical microbial genomes to show that antibiotic resistance genes existed before antibiotics were introduced but became more frequent and mobile with antibiotic use.

Microbial Genomics · Sep 1, 2025Peer-reviewedMicrobiology

Evolutionary dynamics of pro-inflammatory caspases in primates and rodents

Mische Holland, Rachel Rutkowski, Tera C. Levin

This study examines the evolutionary history of pro-inflammatory caspases in primates and rodents, revealing differences in gene retention, pseudogenization, and positive selection across species.

Molecular Biology and Evolution · Oct 17, 2024Peer-reviewedEvolutionary Biology